Multiple comparisons in genetic association studies: a hierarchical modeling approach
نویسندگان
چکیده
منابع مشابه
Multiple comparisons in genetic association studies: a hierarchical modeling approach.
Multiple comparisons or multiple testing has been viewed as a thorny issue in genetic association studies aiming to detect disease-associated genetic variants from a large number of genotyped variants. We alleviate the problem of multiple comparisons by proposing a hierarchical modeling approach that is fundamentally different from the existing methods. The proposed hierarchical models simultan...
متن کاملUsing hierarchical modeling in genetic association studies with multiple markers: application to a case-control study of bladder cancer.
BACKGROUND Genetic association studies are generating much information, usually in the form of single nucleotide polymorphisms in candidate genes. Analyzing such data is challenging, and raises issues of multiple comparisons and potential false-positive associations. Using data from a case-control study of bladder cancer, we showed how to use hierarchical modeling in genetic epidemiologic studi...
متن کاملA new dawn for genetic association studies in multiple sclerosis
Before the genomics technology revolution allowed us to do genome-wide science, genetics research relied on our limited knowledge about a subject to generate hypothesis and candidate genes to study. Despite the level of naiveté, several associations with susceptibility to a complex disease such as multiple sclerosis (MS) were discovered. Of these, HLA-DRB1 and IL7R (1) stand out as being confir...
متن کاملEnriching the analysis of genomewide association studies with hierarchical modeling.
Genomewide association studies (GWAs) initially investigate hundreds of thousands of single-nucleotide polymorphisms (SNPs), and the most promising SNPs are further evaluated with additional subjects, for replication or a joint analysis. Deciding which SNPs merit follow-up is one of the most crucial aspects of these studies. We present here an approach for selecting the most-promising SNPs that...
متن کاملModeling Haplotype-Haplotype Interactions in Case-Control Genetic Association Studies
Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature. In this article, we describe a statistical model for testing haplotype-haplotype interactions for human diseases with a case-control genetic ass...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistical Applications in Genetics and Molecular Biology
سال: 2014
ISSN: 1544-6115,2194-6302
DOI: 10.1515/sagmb-2012-0040